Spotlight on Antibodies

Spotlight on Antibodies is a podcast from ⁠Biointron⁠, where we bring you the latest antibody industry trends. This month in August, we'll talk about engineering peptides into antibodies, the ADC therapeutic window, and targeting autoimmune memory.

References:

1. https://febs.onlinelibrary.wiley.com/doi/full/10.1002/1873-3468.70430
2. https://pmc.ncbi.nlm.nih.gov/articles/PMC9913659/
3. https://ascopubs.org/doi/10.1200/EDBK-25-473916
4. https://pmc.ncbi.nlm.nih.gov/articles/PMC12171081/
5. https://pmc.ncbi.nlm.nih.gov/articles/PMC11860616/
6. https://argenx.com/news/2026/press-release-3333257
7. https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2025.1634090/full

Spotlight on Antibodies is a podcast from ⁠⁠Biointron⁠, where we bring you the latest antibody industry trends. This month from July, we'll highlight antibodies for IVD applications, the druggable proteome, and degrader-antibody conjugates.

References:

1. https://finance.yahoo.com/healthcare/articles/ivd-raw-materials-market-report-093700548.html
2. https://onlinelibrary.wiley.com/doi/full/10.1002/VIW.20240017
3. https://www.cell.com/molecular-therapy-family/molecular-therapy/fulltext/S1525-0016(26)00477-6
4. https://www.nature.com/articles/s41392-023-01589-z
5. https://pmc.ncbi.nlm.nih.gov/articles/PMC13292028/
6. https://www.nature.com/articles/s41571-023-00850-2
7. https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2025.1516419/full

Spotlight on Antibodies is a podcast from ⁠Biointron⁠, where we bring you the latest antibody industry trends. This month in June, we'll highlight the era of AI-driven antibody discovery.

References:

1. https://finance.yahoo.com/sectors/healthcare/articles/ai-antibody-discovery-market-research-080100551.html
2. https://pmc.ncbi.nlm.nih.gov/articles/PMC12298131/#B9-pharmaceuticals-18-00981
3. https://www.biospace.com/press-releases/pharmaceutical-cro-cdmo-market-forecast-from-usd-254-65-bn-to-usd-594-07-bn-by-2035
4. https://www.frontiersin.org/journals/drug-discovery/articles/10.3389/fddsv.2024.1339697/full
5. https://www.sciencedirect.com/science/article/pii/S0959440X26000540
6. https://www.sciencedirect.com/science/article/abs/pii/S0959440X25001022

Spotlight on Antibodies is a podcast from ⁠Biointron⁠, where we bring you the latest antibody industry trends. This month in May, we'll highlight the future of VHH technology, chemical conjugation in antibody therapeutics, and emerging trends in antibody characterization.

References:

1. https://www.tandfonline.com/doi/full/10.1080/19420862.2025.2516676
2. https://academic.oup.com/peds/article/doi/10.1093/protein/gzaf010/8262225
3. https://academic.oup.com/bioinformaticsadvances/article/4/1/vbae033/7623636
4. https://www.nature.com/articles/s42003-026-09594-y
5. https://pubs.acs.org/doi/10.1021/polymscitech.5c00080
6. https://pmc.ncbi.nlm.nih.gov/articles/PMC12203927/
7. https://link.springer.com/article/10.1186/s11671-025-04200-2
8. https://pubs.acs.org/doi/full/10.1021/acs.bioconjchem.3c00040
9. https://www.nature.com/articles/s41598-023-43431-0
10. https://www.cell.com/cell-reports-methods/fulltext/S2667-2375(26)00116-5
11. https://www.mdpi.com/1424-8247/16/2/291

Spotlight on Antibodies is a podcast from ⁠Biointron⁠, where we bring you the latest antibody industry trends. This month, in April, we'll highlight ATP-dependent switch antibodies, the throughput-quality gap in antibody discovery, and multiple myeloma antibody treatments.

References:   

1. https://link.springer.com/article/10.1007/s40259-025-00752-y
2. https://www.sciencedirect.com/science/article/pii/S221112472031531X
3. https://link.springer.com/article/10.1208/s12248-026-01238-7
4. https://www.annalsofoncology.org/article/S0923-7534(25)03071-6/fulltext
5. https://aacrjournals.org/cancerdiscovery/article/11/1/158/2793/Antibody-to-CD137-Activated-by-Extracellular
6. https://link.springer.com/article/10.1208/s12248-026-01238-7
7. https://jitc.bmj.com/content/14/1/e013397
8. https://link.springer.com/article/10.1007/s40200-024-01386-7
9. https://link.springer.com/article/10.1186/s13036-025-00513-z
10. https://academic.oup.com/abt/article/6/1/13/6823522
11. https://www.clinical-lymphoma-myeloma-leukemia.com/article/S2152-2650(24)02423-6/fulltext

Spotlight on Antibodies is a podcast from ⁠Biointron⁠, where we bring you the latest antibody industry trends. This month in March, we'll highlight antibody allostery, trends in developability, and anti-IgE therapeutics. 

References:

1. https://www.sciencedirect.com/science/article/abs/pii/S0734975024001769
2. https://www.tandfonline.com/doi/full/10.1080/19420862.2017.1367074#abstract
3. https://www.mdpi.com/2304-8158/14/8/1360
4. https://www.sciencedirect.com/science/article/pii/S002228362500381X
5. https://www.nature.com/articles/s41467-025-65666-3
6. https://www.tandfonline.com/doi/full/10.1080/19420862.2023.2185924#abstract
7. https://www.fiercebiotech.com/sponsored/why-early-developability-assessment-strategic-necessity-modern-antibody-discovery
8. https://www.tandfonline.com/doi/full/10.1080/19420862.2025.2562999
9. https://www.tandfonline.com/doi/full/10.1080/19420862.2025.2593055%4010.1080/tfocoll.2023.0.issue-biologics-developability
10. https://www.tandfonline.com/doi/full/10.1080/19420862.2026.2627669
11. https://www.frontiersin.org/journals/allergy/articles/10.3389/falgy.2026.1759921/full
12. https://www.biospace.com/press-releases/poplar-therapeutics-closes-45-million-series-a-extension-to-advance-development-of-lead-program-phb-050-a-new-class-of-anti-ige-therapy-for-multiple-atopic-conditions
13. https://excellergy.com/excellergy-to-be-acquired-by-novartis-for-up-to-usd-2-billion-to-advance-potentially-first-in-class-trifunctional-effector-cell-response-inhibitors/

Spotlight on Antibodies is a podcast from ⁠Biointron⁠, where we bring you the latest antibody industry trends. This month in February, we'll highlight radioantibodies, antibody-cytokine fusion proteins, and conditionally active antibodies.

References:

1. https://www.mdpi.com/2072-6694/17/21/3412
2. https://www.sciencedirect.com/science/article/abs/pii/S0001299896800201?via%3Dihub
3. https://swissrockets.com/news/swiss-rockets-group-alloy-therapeutics-partner-to-advance-radioligand-therapeutics-in-oncology
4. https://www.northstarnm.com/convergent-therapeutics-and-northstar-medical-radioisotopes-announce-expanded-partnership-to-support-convergents-late-stage-alpha-emitting-radioantibody-program/
5. https://www.businesswire.com/news/home/20250612596008/en/Debiopharm-and-Alkyon-Therapeutics-Announce-Research-Collaboration-to-Advance-the-Next-Generation-of-Radioligand-Therapies
6. https://pmc.ncbi.nlm.nih.gov/articles/PMC6994257/
7. https://www.tandfonline.com/doi/full/10.1080/19420862.2025.2590250
8. https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2025.1498697/full
9. https://www.sciencedirect.com/science/article/pii/S0305737225000593
10. https://jitc.bmj.com/content/13/4/e010566
11. https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2025.1640427/full
12. https://www.sciencedirect.com/science/article/pii/S2468294224000170?via%3Dihub
13. https://ascopubs.org/doi/10.1200/JCO.2025.43.16_suppl.3077
14. https://pubs.acs.org/doi/10.1021/jacs.5c16108

Spotlight on Antibodies is a podcast from ⁠Biointron⁠, where we bring you the latest antibody industry trends. This month in January, we'll do a deep dive into last year's novel antibody drugs, G protein-coupled receptors, and fusion proteins.

References:

1. https://www.biointron.com/antibody-industry-trends/q4-2025-biointron-antibody-industry-insights-report.html
2. https://www.cell.com/trends/pharmacological-sciences/abstract/S0165-6147(25)00284-6
3. https://firstwordpharma.com/story/7047344
4. https://www.tandfonline.com/doi/10.1080/17460441.2023.2193389
5. https://currentprotocols.onlinelibrary.wiley.com/doi/10.1002/cpz1.1061
6. https://linkinghub.elsevier.com/retrieve/pii/S0165614721001899
7. https://academic.oup.com/jimmunol/article/214/3/565/8052974
8. https://www.nature.com/articles/s44386-025-00015-4
9. https://doi.org/10.3389/fimmu.2025.1498697
10. https://www.sciencedirect.com/science/article/pii/S2950588725000060

Spotlight on Antibodies is a podcast from ⁠Biointron⁠, where we bring you the latest antibody industry trends. This December, we'll highlight the antibody startup ecosystem, microfluidic strategies driving next-generation antibody discovery, and the landscape of psoriasis treatment.

References:

1. https://www.mdpi.com/2079-6374/15/7/409
2. https://www.tandfonline.com/doi/full/10.1080/19420862.2025.2597610?src=
3. https://www.nature.com/articles/s41587-024-02346-5
4. https://pubs.rsc.org/en/content/articlehtml/2025/lc/d5lc00340g
5. https://www.sciencedirect.com/science/article/pii/S2667237524003242
6. https://www.nature.com/articles/s41551-025-01411-x
7. https://pmc.ncbi.nlm.nih.gov/articles/PMC11417777/
8. https://www.prnewswire.com/news-releases/chinas-first-domestic-il-23p19-monoclonal-antibody-innovents-pecondle-picankibart-injection-received-nmpa-approval-302627980.html
9. https://www.nature.com/articles/d41586-025-02649-w
10. https://www.mdpi.com/1422-0067/26/19/9616

Spotlight on Antibodies is a podcast from ⁠Biointron⁠, where we bring you the latest antibody industry trends. This November, we'll highlight how non-canonical antibodies are reshaping immunotherapy, combination antibody therapies, and T cell exhaustion.

References:

1. https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2025.1723343/full
2. https://www.tandfonline.com/doi/10.1080/19420862.2025.2583210#abstract
3. https://www.cancertreatmentreviews.com/article/S0305-7372(15)00193-0/abstract
4. https://link.springer.com/article/10.1186/s13045-023-01509-2
5. https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2025.1556245/full
6. https://link.springer.com/article/10.1186/s12879-025-11012-3
7. https://www.sciencedirect.com/science/article/pii/S2274580724005934
8. https://onlinelibrary.wiley.com/doi/10.1002/ctm2.70345
9. https://www.pnas.org/doi/10.1073/pnas.2409564122
10. https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2024.1507501/full
11. https://www.nature.com/articles/s41577-019-0221-9
12. https://www.sciencedirect.com/science/article/pii/S1074761325003711

Spotlight on Antibodies is a podcast from ⁠Biointron⁠, where we bring you the latest antibody industry trends. This October, we'll highlight advances in antibody design with AI, crossing the BBB, and universal antibodies. 

References:

1. https://biomarkerres.biomedcentral.com/articles/10.1186/s40364-025-00764-4
2. https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2025.1637602/full
3. https://pubs.acs.org/doi/10.1021/acs.bioconjchem.5c00379
4. https://www.nature.com/articles/s41467-025-59447-1
5. https://www.sciencedirect.com/science/article/pii/S0165614725001828
6. https://pmc.ncbi.nlm.nih.gov/articles/PMC12306175/
7. https://pubs.acs.org/doi/10.1021/acsami.4c18679
8. https://www.nature.com/articles/s41590-025-02286-5
9. https://www.science.org/doi/10.1126/sciadv.adx3505
10. https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(25)00481-5/abstract
11. https://pubs.acs.org/doi/10.1021/acsnano.5c08128
12. https://www.cell.com/cell/fulltext/S0092-8674(25)01032-3

Spotlight on Antibodies is a podcast from ⁠Biointron⁠, where we bring you the latest antibody industry trends. This September we'll highlight recent approvals in biosimilar drugs, conjugate linker designs, and discovery platform advances.

References

1. https://bmcimmunol.biomedcentral.com/articles/10.1186/s12865-025-00693-9
2. https://pmc.ncbi.nlm.nih.gov/articles/PMC12185665/
3. https://www.prnewswire.com/news-releases/professor-sarfaraz-k-niazi-secures-first-ever-fda-acceptance-to-waive-clinical-efficacy-studies-for-monoclonal-antibody-biosimilars-302542781.html
4. https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/cmdc.202500262
5. https://pubs.acs.org/doi/10.1021/acs.jmedchem.5c01500
6. https://www.sciencedirect.com/org/science/article/pii/S1520480424010044
7. https://www.nature.com/articles/s41598-025-13810-w
8. https://www.mdpi.com/1424-8247/18/8/1198
9. https://jbioleng.biomedcentral.com/articles/10.1186/s13036-025-00513-z
10. https://news.illinois.edu/high-volume-antibody-testing-platform-could-accelerate-disease-research-and-treatment-development/
11. https://pmc.ncbi.nlm.nih.gov/articles/PMC11623700/
12. https://pubs.rsc.org/en/content/articlehtml/2025/lc/d5lc00340g

Spotlight on Antibodies is a podcast from ⁠Biointron⁠, where we bring you the latest antibody industry trends. This August, we highlight drug advances in autoimmune and infectious diseases, as well as next-generation immune cell engagers.

References:

1. Pelkas, C., Franke, K. B., Vincent, F. B., & Rischmueller, M. (2025). Novel therapies in Sjögren’s disease: A systematic review of the literature. Best Practice & Research Clinical Rheumatology, 102084. https://doi.org/10.1016/j.berh.2025.102084
2. Subramaniam, S., Saville, J. W., Feng, F., & Freiburger, L. (2025). Therapeutic Antibodies for Infectious Diseases: Recent Past, Present, and Future. Biochemistry. https://doi.org/10.1021/acs.biochem.5c00192
3. Atanasov, P. Y., Moneva-Sakelarieva, M. G., Kobakova, Y. A., Ivanova, S. A., Becheva, M. V., Kirkova-Bogdanova, A. G., Chaneva, M. S., Atanasova, V. P., Todorov, R. F., Bashev, N. Z., Bashov, I. E., & Ibrahim, A. H. (2025). Monoclonal antibodies: their place in applied medicine and their role in the newest infectious disease – history, present, and future. Literature review. Pharmacia, 72, 1–18. https://doi.org/10.3897/pharmacia.72.e159772
4. Fucà, G., Spagnoletti, A., Ambrosini, M., De Braud, F., & Di Nicola, M. (2021). Immune cell engagers in solid tumors: Promises and challenges of the next generation immunotherapy. ESMO Open, 6(1), 100046. https://doi.org/10.1016/j.esmoop.2020.100046
5. In, H., Park, M., Lee, H., & Han, K. H. (2025). Immune Cell Engagers: Advancing Precision Immunotherapy for Cancer Treatment. Antibodies, 14(1), 16. https://doi.org/10.3390/antib14010016
6. Albayrak, G., Wan, P. K., Fisher, K., & Seymour, L. W. (2025). T cell engagers: Expanding horizons in oncology and beyond. British Journal of Cancer, 1-9. https://doi.org/10.1038/s41416-025-03125-y‌

Spotlight on Antibodies is a podcast from ⁠Biointron⁠, where we bring you the latest antibody industry trends. This July, recent research includes computational tools for nanodiscs, antibody-drug conjugate (ADC) development, and antibody-antigen research.

References:

1. Yao, X., & Thomson, C. A. (2025). Review: Membrane protein nanodiscs for antibody discovery. Current Opinion in Structural Biology, 94, 103104. https://doi.org/10.1016/j.sbi.2025.103104
2. Baskakova, K. O., Kuzmichev, P. K., & Karbyshev, M. S. (2024). Advanced applications of Nanodiscs-based platforms for antibodies discovery. Biophysical Chemistry, 313, 107290. https://doi.org/10.1016/j.bpc.2024.107290
3. Dong, Y., Tang, H., Dai, H., Zhao, H., & Wang, J. (2024). The application of nanodiscs in membrane protein drug discovery & development and drug delivery. Frontiers in Chemistry, 12, 1444801. https://doi.org/10.3389/fchem.2024.1444801
4. Kuai, R., Yuan, W., Son, S., Nam, J., Xu, Y., Fan, Y., Schwendeman, A., & Moon, J. J. (2018). Elimination of established tumors with nanodisc-based combination chemoimmunotherapy. Science Advances. https://doi.org/aao1736
5. Noriega, H. A., & Wang, X. S. (2025). AI-driven innovation in antibody-drug conjugate design. Frontiers in Drug Discovery, 5, 1628789. https://doi.org/10.3389/fddsv.2025.1628789
6. Croitoru, A., Orr, A. A., & MacKerell, A. D. (2025). Harnessing computational technologies to facilitate antibody–drug conjugate development. Nature Chemical Biology, 21(8), 1138-1147. https://doi.org/10.1038/s41589-025-01950-z
7. Chen, L., Li, B., Chen, Y., Lin, M., Zhang, S., Li, C., Pang, Y., & Wang, L. (2025). ADCNet: A unified framework for predicting the activity of antibody-drug conjugates. Briefings in Bioinformatics, 26(3). https://doi.org/10.1093/bib/bbaf228
8. Su, A., Luo, Y., Zhang, C., & Duan, H. (2025). Linker-GPT: Design of Antibody-drug conjugates linkers with molecular generators and reinforcement learning. Scientific Reports, 15(1), 1-15. https://doi.org/10.1038/s41598-025-05555-3
9. Sato, K., Uehara, S., Tsugita, A., Ishii, M., Ishiyama, S., Maejima, A., Nakahara, I., Nazuka, M., Matsui, T., Christos, G., Yokoyama, T., Kumagai, I., Makabe, K., Asano, R., & Tanaka, Y. (2025). Bispecific antibody-antigen complex structures reveal activity enhancement by domain rearrangement. Cell reports, 44(7), 115965. https://doi.org/10.1016/j.celrep.2025.115965
10. Myung, Y., Pires, D. E., & Ascher, D. B. (2023). Understanding the complementarity and plasticity of antibody–antigen interfaces. Bioinformatics, 39(7). https://doi.org/10.1093/bioinformatics/btad392
11. Heirene, L., Byrne, H., Sepp, A., Gaffney, E., & Yates, J. (2025). Understanding antibody-target antigen interactions and the avidity effect using mathematical modelling. Journal of the Royal Society, Interface, 22(228), 20240710. https://doi.org/10.1098/rsif.2024.0710
12. Torrents de la Peña, A., Sewall, L. M., de Paiva Froes Rocha, R., Jackson, A. M., Pratap, P. P., Bangaru, S., Cottrell, C. A., Mohanty, S., Shaw, A. C., & Ward, A. B. (2023). Increasing sensitivity of antibody-antigen interactions using photo-cross-linking. Cell reports methods, 3(6), 100509. https://doi.org/10.1016/j.crmeth.2023.100509
13. Manion, A., Brooks, T. M., & Brooks, C. L. (2025). Antibody-Antigen Epitope Mapping by X-Ray Crystallography. Methods in molecular biology (Clifton, N.J.), 2937, 15–31. https://doi.org/10.1007/978-1-0716-4591-8_2

Spotlight on Antibodies is a podcast from Biointron, where we bring you the latest antibody industry trends. This June, recent research includes VHH antibodies, antibody-drug conjugates in oncology, and antibody engineering as a countermeasure to drug resistance.